Product Name	mSin3A
Chinese Name	同源转录调节蛋白Sin3A抗体
Alias	Histone deacetylase complex subunit Sin 3a; Histone deacetylase complex subunit Sin3a; Paired amphipathic helix protein Sin 3a; Paired amphipathic helix protein Sin3a; Sin 3a; SIN3 homolog A; SIN3 homolog A transcription regulator (yeast); SIN3 homolog A transcription regulator; Sin3a; SIN3A protein; Transcriptional co repressor Sin 3A; Transcriptional co repressor Sin3A; Transcriptional regulator SIN3A; SIN3A_MOUSE.
literatures	Specific References  (1)     |     SL4230R has been referenced in 1 publications. [IF=4.12] Zheng et al. The Modification of Tet1 in Male Germline Stem Cells and Interact with PCNA, HDAC1 to promote their Self-renewal and Proliferation. (2016) Sci.Rep. 6:37414  WB ;  Goat.   PubMed:27857213
Research Area	Tumour  Cell biology  immunology  Signal transduction  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	145kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Sin3A: 551-650/1274
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Mammalian Sin 3 (mSin 3) is a protein closely related to the yeast SIN3 repressor protein involved in the transcriptional repression of many genes. There are two mammalian isoforms, mSin 3A and mSin 3B. Containing 4 paired amphipathic helix domains (PAH domains), mSin 3A and mSin 3B have been shown to directly interact with several other transcriptional repressor proteins including HDAC 1, HDAC 2, RbAp 46, the methyl CpG binding protein MeCP 2, the Mad/Max heterodimer, and the corepressors silencing mediator of retinoic acid & thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR). Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Subunit: Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity). Interacts with BAZ2A, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Subcellular Location: Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L (By similarity). Tissue Specificity: Widely expressed. Highest levels in testis, lung and thymus. Post-translational modifications: SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2 (By similarity). Similarity: Contains 3 PAH (paired amphipathic helix) domains. SWISS: Q60520 Gene ID: 20466 Database links: Entrez Gene: 25942 Human Entrez Gene: 20466 Mouse Entrez Gene: 363067 Rat Omim: 607776 Human SwissProt: Q96ST3 Human SwissProt: Q60520 Mouse Unigene: 513039 Human Unigene: 15755 Mouse Unigene: 63749 Rat

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