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Product Name VAPA Chinese Name 囊泡相关膜蛋白相关蛋白A抗体 Alias VAMP A; VAMP associated protein A; VAP 33; VAP A; VAP33; Vesicle associated membrane protein associated protein A; VAPA_HUMAN. Research Area Tumour Cell biology immunology Signal transduction Cell adhesion molecule Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human VAPA: 101-200/249 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail VAPA is a type IV membrane protein, present in the plasma membrane, intracellular vesicles and may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Two transcript variants encoding distinct isoforms have been identified.
Function:
May play a role in vesicle trafficking.
Subunit:
Homodimer, and heterodimer with VAPB. Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the C-terminal domain of OCLN. Interacts with OSBPL1A. Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in the endoplasmic reticulum and regulate its function in cell projections formation.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. Contains 1 MSP domain.
SWISS:
Q9P0L0
Gene ID:
9218
Database links:Entrez Gene: 9218 Human
Entrez Gene: 30960 Mouse
Omim: 605703 Human
SwissProt: Q9P0L0 Human
SwissProt: Q9WV55 Mouse
Unigene: 165195 Human
Unigene: 266767 Mouse
Unigene: 162275 Rat
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