Product Name	Cullin 2
Chinese Name	Cullin2抗体
Alias	Cullin2; Cullin-2; CUL 2; MGC131970; CUL2_HUMAN.
Research Area	Tumour  Cell biology  immunology  Chromatin and nuclear signals  Signal transduction  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	87kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Cullin 2: 365-745/745
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cullin 2 is a member of the family of human Cullin genes (CUL1, 2, 3, 4a, 4b and 5) homologous to the S. cerevisiae cdc53 gene. It is a component of E3 ubiquitin ligase complexes, including the inactive transcriptional elongation complex SIII, which mediates the ubiquitination of hypoxia-inducible factor (HIF). SIII is formed by three subunits: Elongin C, Elongin B and VHL. Cullin 2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Function: Core component of multiple cullin-RING-based ECS(ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligasecomplexes, which mediate the ubiquitination of target proteins. Mayserve as a rigid scaffold in the complex and may contribute tocatalysis through positioning of the substrate and theubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of thecullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1 (By similarity). Thefunctional specificity of the ECS complex depends on the substraterecognition component. ECS(VHL) mediates the ubiquitination ofhypoxia-inducible factor (HIF). Subunit: Component of multiple ECS (Elongin BC-CUL2/5-SOCS-boxprotein) E3 ubiquitin-protein ligase complexes formed of CUL2,Elongin BC (TCEB1 and TCEB2), RBX1 and a variablesubstrate-specific adapter. Component of the ECS(VHL) or CBC(VHL)complex containing VHL. Component of the ECS(MED8) complex with theprobable substrate recognition component MED8 (By similarity).Component of the ECS(LRR1) complex with the probable substraterecognition component LRR1. Component of a probable ECS E3ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1,TCEB2 and FEM1B. Part of an E3 ubiquitin-protein ligase complexincluding ZYG11B, CUL2 and Elongin BC. Part of an E3ubiquitin-protein ligase complex including ZYG11BL, CUL2 andElongin BC. Interacts with RBX1, RNF7, FEM1B and TIP120A/CAND1.Interacts with COPS2, and MED8 (By similarity). Interacts withhuman respiratory syncytial virus (HRSV) protein NS1. Found in acomplex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Post-translational modifications: CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. Similarity: Belongs to the cullin family. SWISS: Q13617 Gene ID: 8453 Database links: Entrez Gene: 535219 Cow Entrez Gene: 477952 Dog Entrez Gene: 101152077 Gorilla Entrez Gene: 100054982 Horse Entrez Gene: 8453 Human Entrez Gene: 100395340 Marmoset (common) Entrez Gene: 101051445 Monkey Entrez Gene: 71745 Mouse Entrez Gene: 100018154 Opossum Entrez Gene: 100174361 Orangutan Entrez Gene: 100512186 Pig Entrez Gene: 100074001 Platypus (Ornithorhynchus anatinus) Entrez Gene: 100343513 Rabbit Entrez Gene: 361258 Rat Entrez Gene: 100550749 Turkey Entrez Gene: 336088 Zebrafish Omim: 603135 Human SwissProt: Q13617 Human SwissProt: Q9D4H8 Mouse SwissProt: Q5RCF3 Orangutan Unigene: 82919 Human Unigene: 291707 Mouse Unigene: 443148 Mouse

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