Product Name	Endothelin B Receptor
Chinese Name	内皮素B受体抗体
Alias	ABCDS; Ednra; Ednrb; EDNRB_HUMAN; Endothelin B receptor; Endothelin B receptor precursor; Endothelin receptor Non selective type; Endothelin receptor non-selective type; Endothelin receptor type B; ET B; ET-B; ET-BR; ETB; ETRB; Hirschsprung disease 2; HSCR; HSCR2; EDNRB; HSCR; WS4A.
literatures	Specific References  (4)     |     SL4198R has been referenced in 4 publications. [IF=10.787] Ravi Kumar. et al. Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cells. REDOX BIOL. 2022 Sep;55:102394  WB ;  Pig.   PubMed:35841629 [IF=4.757] Nataliia Hula. et al. The Long-Term Effects of Prenatal Hypoxia on Coronary Artery Function of the Male and Female Offspring. BIOMEDICINES. 2022 Dec;10(12):3019  IF ;  Rat.   PubMed:10.3390/biomedicines10123019 [IF=2.107] Ji L et al. A high affinity nanobody against endothelin receptor type B: a new approach to the treatment of melanoma. Mol Biol Rep. 2020 Mar;47(3):2137-2147.  WB ;  Human.   PubMed:32080807 [IF=0.939] Prayitnaningsih et al. Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats. (2016) Int.J.Ophthalmol. 9:1568-1577  IF(IHC-P) ;  Rat.   PubMed:27990358
Research Area	Cardiovascular  immunology  Signal transduction  G protein-coupled receptor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	47kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Endothelin B Receptor: 378-442/442 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. Post-translational modifications: Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405. DISEASE: Defects in EDNRB are a cause of Waardenburg syndrome type 4A (WS4A) [MIM:277580]; also known as Waardenburg-Shah syndrome. WS4A is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). Defects in EDNRB are the cause of Hirschsprung disease type 2 (HSCR2) [MIM:600155]; also known as aganglionic megacolon (MGC). HSCR2 is a congenital disorder characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child. Defects in EDNRB are the cause of ABCD syndrome (ABCDS) [MIM:600501]. ABCD syndrome is an autosomal recessive syndrome characterized by albinism, black lock at temporal occipital region, bilateral deafness, aganglionosis of the large intestine and total absence of neurocytes and nerve fibers in the small intestine. Similarity: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. SWISS: P24530 Gene ID: 1910 Database links: Entrez Gene: 408082 Chicken Entrez Gene: 281750 Cow Entrez Gene: 100033875 Horse Entrez Gene: 1910 Human Entrez Gene: 13618 Mouse Entrez Gene: 100009477 Rabbit Entrez Gene: 50672 Rat Omim: 131244 Human SwissProt: P28088 Cow SwissProt: O62709 Horse SwissProt: P24530 Human SwissProt: P48302 Mouse SwissProt: P35463 Pig SwissProt: Q9N0W7 Rabbit SwissProt: P21451 Rat Unigene: 487 Cow Unigene: 13045 Horse Unigene: 82002 Human Unigene: 229532 Mouse Unigene: 27603 Pig Unigene: 6857 Rabbit Unigene: 11412 Rat
Product Picture	Sample: Lane1:Heart (Rat)Lysate at 40 ug Lane2:Heart (Mouse) Lysate at 40 ug Primary: Anti-Endothelin B Receptor(SL4198R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 47kD Observed band size: 50kD Sample: Lane 1: Embryo (Mouse) Tissue Lysate at 40 ug Lane 2: Lung (Mouse) TissueLysate at 40 ug Lane 3: Cerebrum (Mouse) Tissue Lysate at 40 ug Lane 4: Cerebrum (Rat) Tissue Lysate at 40 ug Lane 5: A431 (Human) Cell Lysate at 30 ug Lane 6: BV-2 (Mouse) Cell Lysate at 30 ug Lane 7: SH-SY5Y (Human) Cell Lysate at 30 ug Primary: Anti-Endothelin B Receptor (SL4198R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 50 kD Overlay histogram showing SP2/0 cells stained with SL4198R-PE (red line). The cells were fixed with 1%paraformaldehyde (10 min) and then permeabilized with 1x PBS /0.2%TritonX-100 for 5 min. The cells were then incubated in 1x PBS / 1%BSA to block non-specific protein-protein interactions. The cells were then incubated with the antibody (SL4198R-PE, 2ug/1x106 cells) for 30 min at 22-25°C. Isotype control antibody (black line) was rabbit IgG (2ug/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

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