Product Name	PTGER2
Chinese Name	前列腺素E2受体2抗体
Alias	EP 2; EP2; Prostaglandin E Receptor EP2; Human prostaglandin E2 receptor; PE2R2_HUMAN; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostaglandin E receptor 2 EP2 subtype; Prostaglandin E receptor 2 subtype EP2 53kDa; Prostaglandin E receptor 2 subtype EP2; Prostaglandin E2 receptor; Prostaglandin E2 receptor EP2 subtype; Prostanoid EP2 receptor; PTGER 2; PTGER2.
literatures	Specific References  (4)     |     SL4196R has been referenced in 4 publications. [IF=4.872] Wu F et al. Manganese exposure caused reproductive toxicity of male mice involving activation of GnRH secretion in the hypothalamus by prostaglandin E2 receptors EP1 and EP2. Ecotoxicol Environ Saf . 2020 Sep 15;201:110712.  WB ;  Mouse.   PubMed:32502905 [IF=3.23] Takemiya et al. Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis. (2017) Int.J.Mol.Sci. 18  IHC-F ;  Mouse.   PubMed:29257087 [IF=2.253] Chen Z et al. Seasonal expressions of prostaglandin E synthases and receptors in the prostate of the wild ground squirrel (Spermophilus dauricus). Prostaglandins and Other Lipid Mediators 148 (2020) 106412.  IHC-P ;  squirrel.   PubMed:doi:10.1016/j.prostaglandins.2020.106412 [IF=1.76] Müller, Julia J., et al. "Fetal Sheep Mesenteric Resistance Arteries: Functional and Structural Maturation." Journal of vascular research 54.5 (2017): 259-271.  IHC-P ;  Sheep.   PubMed:28810262
Research Area	Tumour  immunology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat, Sheep,  (predicted: Dog, Pig, Cow, Rabbit, )
Applications	WB=1:500-2000 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Prostaglandin E Receptor EP2: 271-358/358 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. Prostaglandin E2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo Prostaglandin E2 induced internalization. The EP2 receptors is involved with the contration and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle. Function: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Placenta and lung. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P43116 Gene ID: 5732 Database links: Entrez Gene: 282329 Cow Entrez Gene: 5732 Human Entrez Gene: 19217 Mouse Entrez Gene: 100360765 Rat Entrez Gene: 81752 Rat Omim: 176804 Human SwissProt: P43116 Human SwissProt: Q62053 Mouse SwissProt: Q62928 Rat Unigene: 2090 Human Unigene: 4630 Mouse Unigene: 10264 Rat
Product Picture	Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Urinary bladder tissue lysates Lane 3: Mouse Placenta tissue lysates Lane 4: Rat Urinary bladder tissue lysates Lane 5: Rat Placenta tissue lysates Lane 6: Human MCF-7 cell lysates Lane 7: Human JAR cell lysates Lane 8: Human HL60 cell lysates Primary: Anti-PTGER2 (SL4196R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 48 kDa Blank control(blue): A549(fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-Prostaglandin E Receptor EP2/AF647 Conjugated antibody (SL4196R-AF647), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/AF647(orange) ,used under the same conditions.

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