Product Name	CBS
Chinese Name	丝氨酸羧甲半胱氨酸合成酶抗体
Alias	Beta thionase; Beta-thionase; Cbs; CBS_HUMAN; Cystathionine beta synthase; Cystathionine beta-synthase; HIP 4; HIP4; Methylcysteine synthase; Serine sulfhydrase.
literatures	Specific References  (2)     |     SL4193R has been referenced in 2 publications. [IF=6.543] Yuan Jiyan. et al. Vitamin B12 Attenuates Acute Pancreatitis by Suppressing Oxidative Stress and Improving Mitochondria Dysfunction via CBS/SIRT1 Pathway. Oxid Med Cell Longev. 2021;2021:7936316  WB ;  Mouse.   PubMed:34925701 [IF=2.53] Shiina, Takahiko, et al. "Inhibitory action of hydrogen sulfide on esophageal striated muscle motility in rats." European Journal of Pharmacology (2016).  WB ;  Rat.   PubMed:26687631
Research Area	immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	61kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HIP4: 177-280/400
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2010]. SWISS: P35520 Gene ID: 875 Database links: Entrez Gene: 875 Human Entrez Gene: 12411 Mouse Entrez Gene: 24250 Rat Omim: 613381 Human SwissProt: P35520 Human SwissProt: Q91WT9 Mouse SwissProt: P32232 Rat Unigene: 533013 Human
Product Picture	Sample: Liver(Mouer) Cell Lysate at 40 ug Primary: Anti-CBS (SL4193R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61 kD Observed band size: 61 kD Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CBS) Polyclonal Antibody, Unconjugated (SL4193R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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