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Product Name P2Y2 Chinese Name 嘌呤ATP受体抗体 Alias P2Y2R; ATP receptor; HP2U; Human P2U nucleotide receptor mRNA complete cds; P2RU1; P2RY2; P2RY2_HUMAN; P2U nucleotide receptor; P2U purinoceptor 1; P2U1; P2UR; P2Y purinoceptor 2; P2Y2; P2Y2R; Purinergic receptor; Purinergic receptor P2Y G protein coupled 2; Purinergic receptor P2Y2; Purinoceptor P2Y2. literatures Specific References (3) | SL4180R has been referenced in 3 publications.[IF=4.162] Zhen-Ni Liu. et al. Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway. DRUG DES DEV THER. Drug Des Dev Ther. 2022 Apr;16:1107-1120 IHC ; Mouse.[IF=3.361] Liu ZN et al. Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation. Int Immunopharmacol. 2019 Oct 19;77:105915. WB ; Mouse.[IF=1.42] Liu, Yuan-Mei, et al. "Expression of the P2Y2 receptor in the terminal rectum of fetal rats with anorectal malformation." International Journal of Clinical and Experimental Medicine 8.2 (2015): 1669-1676. IHC-P ; Rat.Research Area immunology transcriptional regulatory factor G protein-coupled receptor Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Dog, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 41kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human P2Y2R: 21-120/377 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq].
Function:
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Spleen, testis, kidney, liver, lung, heart and brain.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
P41231
Gene ID:
5029
Database links:Entrez Gene: 5029 Human
Entrez Gene: 18442 Mouse
Omim: 600041 Human
SwissProt: P41231 Human
SwissProt: P35383 Mouse
Unigene: 339 Human
Unigene: 3000 Mouse
Unigene: 11102 Rat
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