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Product Name Kv2.1 Chinese Name 钾Channel proteinDRK1抗体 Alias Delayed rectifier potassium channel 1; Delayed rectifier potassium channel Kv2.1; DRK 1; DRK1; h DRK1 K(+) channel; h-DRK1; hDRK 1; hDRK1; KCB 1; KCB1; KCNB1; KCNB1_HUMAN; KV2.1; Potassium channel protein DRK1; Potassium voltage gated channel shab related subfamily member 1; Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel subunit Kv2.1. literatures Specific References (1) | SL4150R has been referenced in 1 publications.[IF=3.8] Pucca, Manuela Berto, et al. "Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K+ channel pattern in T cells." Immunology (2015). Mouse.Research Area immunology The cell membrane受体 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 96kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human DRK1: 465-570/858 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
Subunit:
Heteromultimer with KCNG2, KCNG3, KCNG4, KCNS1, KCNS2, KCNS3 and KCNV2 (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein.
Post-translational modifications:
Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are all regulated by calcineurin-mediated dephosphorylation. Particularly, Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/ dephosphorylation activities. Tyr-128 can be dephosphorylated by PTPalpha and cyt-PTPepsilon. Phosphorylation levels on Ser-607 are supersensitive to neuronal activity. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5. Levels then increase to reach adult levels by P14. Phosphorylation levels on Ser-564 and Ser-607 are greatly reduced during seizures, by 40% and 85% respectively (By similarity).
Similarity:
Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
SWISS:
Q14721
Gene ID:
3745
Database links:Entrez Gene: 3745 Human
Entrez Gene: 16500 Mouse
Omim: 600397 Human
SwissProt: Q14721 Human
SwissProt: Q03717 Mouse
Unigene: 84244 Human
Unigene: 387390 Mouse
Unigene: 26724 Rat
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