Product Name	UMOD
Chinese Name	尿调节蛋白抗体
Alias	Uromodulin; ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; MGC14034; TAMM-HORSFALL; THGP; THP; urehr4; Uromodulin; uromucoid; UROM_MOUSE; UROM_HUMAN;
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 IHC-P=1:400-800 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	69kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human UMOD protein: 316-615/640
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013] SWISS: Q91X17 Gene ID: 7369
Product Picture	Sample: Lane 1: Recombinant human UMOD protein, N-His Primary: Anti-UMOD (SL41397R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 69 kDa Observed band size: 37 kDa Paraformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Uromucoid) Polyclonal Antibody, Unconjugated (SL41397R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Uromucoid) Polyclonal Antibody, Unconjugated (SL41397R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Measured by its binding ability in a indirect ELISA. Immobilized Human UMOD protein, His Tag (Cat. SL41397P) at 2 μg/mL (100 μL/well) can bind  Rabbit Anti-Human UMOD Antibody, the EC50 is 335.3 ng/mL. Measured by its binding ability in a indirect ELISA. Immobilized Human UMOD protein, His Tag (Cat. SL41397P) at 2 μg/mL (100 μL/well) can bind  Rabbit Anti-Human UMOD Antibody, the EC50 is 1218 ng/mL.

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