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Product Name Exendin 4 Chinese Name GLP1类似蛋白Exendin4抗体 Alias Exendin 4; Exendin4; Exendin-4; EXE4_HELSU. literatures Specific References (1) | SL4121R has been referenced in 1 publications.[IF=10.317] Jong Youl Leeet al. Genetic engineering of novel super long-acting Exendin-4 chimeric protein for effective treatment of metabolic and cognitive complications of obesity. Biomaterials . 2020 Oct;257:120250. IHC, IF ; mouse.Research Area immunology Neurobiology Diabetes Immunogen Species Rabbit Clonality Polyclonal Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 4.3kDa Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from Gila monster lizard Exendin 4: 1-39/39 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion.
Function:
Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed by the venom gland.
Similarity:
Belongs to the glucagon family.
SWISS:
P26349
Gene ID:
N/A
Database links:
Exendin-4是从希拉毒蜥唾液中分离的一种多肽激素,由39个氨基酸残基组成,与胰高血糖素样肽1(GLP-1)有53%的同源性。Exendin-4具有高度的组织特异性,仅在希拉毒蜥的唾液腺中表达, 具有促进葡萄糖依赖性的胰岛素分泌、促进β细胞增殖、减慢胃排空、抑制食物摄取和减轻体重等作用。
肠促胰岛素类似物(exendin-4,Ex-4)是从美洲一种毒蜥的唾液中分泌的胰升糖素样肽-1(glucagon-like peptide-1,GLP-1)类似物,它具有促进胰腺胰岛素的分泌、增加胰岛素敏感性及改善胰岛细胞功能的作用,且不被二肽基肽酶Ⅳ(DPP-Ⅳ)分解,血浆半衰期较长,因而在人类,对Diabetes治疗应用来说是稳定、长效的有治疗前景的药物。
钝尾毒蜥 (Gila monster)
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