Product Name	ASAP1
Chinese Name	发育分化增强因子1抗体
Alias	AMAP 1; AMAP1; AMAP-1; ARF GTPase activating protein 1; ASAP 1; Centaurin beta 4; CentB4; DDEF 1; DDEF1 protein; PAG 2; PAG2; PAG-2; PAP; PIP2 dependent ARF1 GAP; ZG 14P; ZG14P; Development and differentiation enhancing factor 1; 130 kDa phosphatidylinositol 4 5 biphosphate dependent ARF1 GTPase activating protein; ADP ribosylation factor directed GTPase activating protein 1; ASAP1_HUMAN.
Research Area	immunology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	125kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ASAP1: 154-190/1129
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ADP-ribosylation factor (Arf) family of small GTP-binding proteins plays a central role in membrane trafficking and cytoskeletal remodeling. ASAP1 (Arf-GAP containing SH3, ankyrin repeats and PH domain) is a phospholipid-dependent Arf GTPase-activating protein that binds to the protein-tyrosine kinases Src and focal adhesion kinase. ASAP1 may act as an oncogene in cancer, and it may be a useful diagnostic marker and therapeutic target. Function: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. Subunit: Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2. Interacts with CTTN. Interacts (via SH3 domain) with APC. Subcellular Location: Cytoplasm. Membrane. Note=Predominantly cytoplasmic. Partially membrane-associated Post-translational modifications: Phosphorylated on tyrosine residues by SRC Similarity: Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain. Contains 1 SH3 domain. SWISS: Q9ULH1 Gene ID: 50807 Database links: Entrez Gene: 50807 Human Entrez Gene: 314961 Rat Omim: 605953 Human SwissProt: Q9ULH1 Human SwissProt: Q9QWY8 Mouse SwissProt: Q1AAU6 Rat Unigene: 106015 Human Unigene: 655552 Human Unigene: 277236 Mouse Unigene: 63466 Rat
Product Picture	Sample: MDA-MB-231 (human)cell Lysate at 40 ug Primary: Anti- ASAP1 (SL4091R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 125kD Observed band size: 125 kD

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