Product Name	DEGS1
Chinese Name	退行性精母细胞同源物1抗体
Alias	Degenerative spermatocyte homolog 1; Degenerative spermatocyte homolog 1 lipid desaturase; Degenerative spermatocyte homolog lipid desaturase; DEGS 1; DEGS; Des 1; DES1; Dihydroceramide desaturase; FADS7; Membrane fatty acid (lipid) desaturase; Membrane lipid desaturase; MGC5079; MIG15v Migration inducing gene 15 protein; MLD; Sphingolipid delta 4 desaturase; Sphingolipid delta(4) desaturase DES1.DEGS1_HUMAN
literatures	Specific References  (2)     |     SL4057R has been referenced in 2 publications. [IF=4.36] Meixia Zhu. et al. Danhe granule ameliorates nonalcoholic steatohepatitis and fibrosis in rats by inhibiting ceramide de novo synthesis related to CerS6 and CerK. J ETHNOPHARMACOL. 2022 May;:115427  WB ;  Rat.   PubMed:35654350 [IF=0.762] Inoue C et al. Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes. Nagoya J Med Sci . 2020 May;82(2):261-280.  WB ;  Human.   PubMed:32581406
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	35kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DEGS1: 21-120/323
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	DEGS1 is a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. It contains three His containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It has sphingolipid-delta-4-desaturase activity and converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Function: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Subcellular Location: Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue Specificity: Ubiquitous. Post-translational modifications: Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels. Similarity: Belongs to the fatty acid desaturase family. DEGS subfamily. SWISS: O15121 Gene ID: 8560 Database links: Entrez Gene: 507290 Cow Entrez Gene: 8560 Human Entrez Gene: 13244 Mouse Entrez Gene: 58970 Rat Entrez Gene: 100192315 Sheep SwissProt: Q3ZBY7 Cow SwissProt: O15121 Human SwissProt: O09005 Mouse SwissProt: Q5XIF5 Rat
Product Picture	Sample: Lane 1: Human Hela cell lysates Lane 2: Human 293T cell lysates Primary: Anti-DEGS1 (SL4057R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kDa Observed band size: 38 kDa

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