Product Name	phospho-PKA beta (Ser339)
Chinese Name	磷酸化蛋白激酶Aβ抗体
Alias	PRKACB (phospho Ser339); PRKACB (phospho S339); PRKACA (phospho Ser339); PRKACA (phospho S339); PKA alpha + beta (catalytic subunits) (phospho S339); PKA alpha + beta (phospho S339); PKA C beta; PKACB; PRKACB; Protein kinase cAMP dependent catalytic beta; cAMP-dependent protein kinase catalytic subunit beta; KAPCB_HUMAN.
literatures	Specific References  (2)     |     SL4024R has been referenced in 2 publications. [IF=5.893] Yongxiang Li. et al. Food reward depends on TLR4 activation in dopaminergic neurons. Pharmacol Res. 2021 Jul;169:105659  WB ;  Mouse.   PubMed:33971268 [IF=2.86] Wu, Junguo, et al. "N-Oleoylglycine-induced hyperphagia was associated with the activation of AgRP neuron by CB1R." Journal of Agricultural and Food Chemistry (2017).  WB ;  Mouse.   PubMed:28102080
Product Type	Phosphorylated anti
Research Area	Tumour  Cell biology  immunology  Signal transduction  transcriptional regulatory factor  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human PKA beta around the phosphorylation site of Ser339: RV(p-S)IT
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Subunit: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity). Subcellular Location: Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity). Tissue Specificity: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. Post-translational modifications: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity). Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. SWISS: P22694 Gene ID: 5567 Database links: Entrez Gene: 282322 Cow Entrez Gene: 282323 Cow Entrez Gene: 5566 Human Entrez Gene: 5567 Human Entrez Gene: 18747 Mouse Entrez Gene: 18749 Mouse Entrez Gene: 25636 Rat Omim: 176892 Human Omim: 601639 Human SwissProt: P00517 Cow SwissProt: P17612 Human SwissProt: P22694 Human SwissProt: P05132 Mouse SwissProt: P05206 Mouse SwissProt: P27791 Rat Unigene: 391 Cow Unigene: 4420 Cow Unigene: 487325 Human Unigene: 631630 Human Unigene: 16766 Mouse Unigene: 19111 Mouse Unigene: 103828 Rat

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