Product Name	Thromboxane synthase
Chinese Name	血栓素合成酶抗体
Alias	CYP5; CYP5A1; Cytochrome P450 5A1; TBXAS1; THAS; Thromboxane A synthase 1 platelet cytochrome P450 subfamily V; TS; TXA synthase; TXAS; TXS.
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	59kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Thromboxane synthase: 451-533/533
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Thromboxane Synthase is a useful marker for the detection of native thromboxane synthase in smears, isolated cells, human tissue sections, and for affinity purification of the enzyme. In combination with the markers 27E10, RM 3/1 and 25F9, anti Thromboxane Synthase enables a more precise characterization of inflammatory processes in injured tissues, or in vitro cell-cell interaction studies. Distribution of thromboxane synthase in human tissues: Thromboxane synthase is predominantly produced by macrophages or antigen presenting cells of the myelo-monocytic lineage as shown below. Endothelial cells of placenta and epithelial cells in tonsils and bronchi also express this enzyme. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. DISEASE: Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all. Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis. Similarity: Belongs to the cytochrome P450 family. SWISS: P24557 Gene ID: 6916 Database links: Entrez Gene: 6916 Human Entrez Gene: 21391 Mouse Entrez Gene: 397112 Pig Entrez Gene: 24886 Rat Omim: 274180 Human SwissProt: P24557 Human SwissProt: P36423 Mouse SwissProt: P47787 Pig SwissProt: P49430 Rat Unigene: 520757 Human Unigene: 4054 Mouse Unigene: 16283 Rat
Product Picture	Sample: U937(Human) Cell Lysate at 30 ug Spleen (Mouse) Lysate at 40 ug Primary: Anti-Thromboxane synthase (SL4019R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 59 kD Sample: A549(Human) Cell Lysate at 30 ug Primary: Anti-Thromboxane synthase (SL4019R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 59 kD

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