Product Name	ATG12
Chinese Name	自噬相关蛋白12抗体
Alias	APG12-like; APG12L; ATG12; ATG12 autophagy related 12 homolog; Autophagy 12; Autophagy-related protein 12; HAPG12; Ubiquitin-like protein ATG12; ATG12_HUMAN.
literatures	Specific References  (2)     |     SL4012R has been referenced in 2 publications. [IF=4.966] Hui Che. et al. Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ‐induced diabetic mice. Faseb J. 2020 Oct;34(10):14042-14054  WB,IF,IHC ;  Mouse, Human.   PubMed:32910484 [IF=2.66] Song, Fuyong, et al. "Involvement of autophagy in tri-ortho-cresyl phosphate-induced delayed neuropathy in hens." Neurochemistry International (2013).  WB ;   PubMed:24220541
Research Area	Tumour  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	15/21kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Apg12: 101-187/187
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998[PubMed 9852036]).[supplied by OMIM]. Function: Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitous. Similarity: Belongs to the ATG12 family. SWISS: O94817 Gene ID: 9140 Database links: Entrez Gene: 9140 Human Entrez Gene: 67526 Mouse Entrez Gene: 361321 Rat Omim: 609608 Human SwissProt: O94817 Human SwissProt: Q9CQY1 Mouse SwissProt: Q2TBJ5 Rat Unigene: 264482 Human Unigene: 9852 Mouse Unigene: 6224 Rat

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