Product Name	eI4EBP2
Chinese Name	eIF4EBinding protein2抗体
Alias	Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.Full=Eukaryotic translation initiation factor 4E-binding protein 2; 4E-BP2; eIF4E-binding protein 2; 4EBP2_HUMAN.
Research Area	Tumour  Cell biology  immunology  Chromatin and nuclear signals  Signal transduction  Apoptosis  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17/20kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human 4E-BP2: 21-120/120
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008] Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway. Subunit: Nonphosphorylated EIF4EBP2 interacts with EIF4E. Post-translational modifications: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Similarity: Belongs to the eIF4E-binding protein family. SWISS: Q13542 Gene ID: 1979 Database links: Entrez Gene: 1979 Human Entrez Gene: 13688 Mouse Entrez Gene: 361845 Rat Omim: 602224 Human SwissProt: Q13542 Human SwissProt: P70445 Mouse Unigene: 621200 Human Unigene: 730236 Human Unigene: 259516 Mouse Unigene: 24129 Rat

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