Product Name	CETP
Chinese Name	胆固醇酯转移蛋白抗体
Alias	BPIFF; CETP; CETP_HUMAN; Cholesteryl ester transfer; Cholesteryl ester transfer protein; Cholesteryl ester transfer protein plasma; Cholesteryl ester transfer protein precursor; HDLCQ10; Lipid transfer protein I.
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Signal transduction  Lipoprotein  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CETP: 355-450/493
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	High density lipoproteins (HDLs) have been proposed to function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease. Function: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. Subcellular Location: Secreted, extracellular space. Tissue Specificity: Expressed by the liver and secreted in plasma. DISEASE: Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. SWISS: P11597 Gene ID: 1071 Database links: Entrez Gene: 1071 Human Omim: 118470 Human SwissProt: P11597 Human SwissProt: P22687 Rabbit Unigene: 89538 Human CETP系一疏水glycoprotein，胆固醇酯Transporter--介导HDL中的胆固醇与VLDL中的甘油三酯等交换，促进HDL中的胆固醇净转运，可促进胆固醇酯在细胞与血浆Lipoprotein间的转运，参与胆固醇的逆转运过程。
Product Picture	Sample: Cerebellum (Mouse) Lysate at 40 ug Primary: Anti- CETP (SL3694R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53 kD

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