Product Name	CK3
Chinese Name	细胞角蛋白3抗体
Alias	Cytokeratin 3; 65 kDa cytokeratin; CK 3; CK-3; CK3; Cytokeratin-3; Cytokeratin3; FLJ95909; K2C3_HUMAN; K3; K3; Keratin 3; Keratin; Keratin type II cytoskeletal 3; Keratin-3; Keratin3; KRT 3; KRT3; type II cytoskeletal 3; Type-II keratin Kb3.
literatures	Specific References  (3)     |     SL3646R has been referenced in 3 publications. [IF=14.593] Binbin He. et al. 3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration. Bioact Mater. 2022 Jan;:  IF ;  Rabbit.   PubMed:10.1016/j.bioactmat.2022.01.034 [IF=3.457] Wu Y et al. Tetramethylpyrazine (TMP) ameliorates corneal neovascularization via regulating cell infiltration into cornea after alkali burn. (2019)Biomedicine & Pharmacotherapy, 109, 1041–1051.  IF ;  Mouse.   PubMed:30551354 [IF=1.291] Duan CY et al. Limbal niche cells can reduce the angiogenic potential of cultivated oral mucosal epithelial cells. Cell Mol Biol Lett. 2019 Apr 4;24:3.  ICF ;  Rat.   PubMed:30988673
Research Area	Tumour  Neurobiology  Signal transduction  Cell type markers  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	65kDa
Cellular localization	cytoplasmic Extracellular matrix
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CK3: 221-320/628
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] Subunit: Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12. Tissue Specificity: Cornea specific. DISEASE: Corneal dystrophy, Meesmann (MECD) [MIM:122100]: An autosomal dominant corneal disease characterized by fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the intermediate filament family. SWISS: P12035 Gene ID: 3850 Database links: Entrez Gene: 281267 Cow Entrez Gene: 3850 Human Omim: 148043 Human SwissProt: P12035 Human SwissProt: Q29426 Rabbit Unigene: 680652 Human

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