Product Name	SUR1
Chinese Name	磺酰脲类药物受体1抗体
Alias	ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.
literatures	Specific References  (1)     |     SL3641R has been referenced in 1 publications. [IF=0.91] Horii K et al. ATP-dependent potassium channels contribute to motor regulation of esophageal striated muscle in rats. J Vet Med Sci. 2019 Jul 9.  IHC-P ;  Rat.   PubMed:31292350
Research Area	immunology  The cell membrane受体  Drugs and Compounds  Diabetes  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Horse, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	175kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SUR1: 301-400/1581 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene. Subunit: Interacts with KCNJ11. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. SWISS: Q09428 Gene ID: 6833 Database links: Entrez Gene: 6833 Human Entrez Gene: 20927 Mouse Entrez Gene: 25559 Rat Omim: 600509 Human SwissProt: Q09428 Human SwissProt: Q09429 Rat Unigene: 54470 Human Unigene: 11187 Rat 胰岛βThe cell membrane含有磺酰脲受体及与之相偶联的ATP敏感的钾通道Ik（ATP），以及电压依赖性的钙通道。当磺酰脲类药物与其受体相结合后，可阻滞Ik（ATP）而阻钾外流，致使The cell membrane去极化，增强电压依赖性钙通道开放，胞外钙内流。胞内游离钙浓度增加后，触发胞吐作用及胰岛素的释放。
Product Picture	Sample: Hippocampus (Mouse) Lysate at 40 ug Primary: Anti-SUR1 (SL3641R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 175 kD Observed band size: 175 kD Sample: Cerebral cortex (Mouse) Lysate at 40 ug Primary: Anti-SUR1 (SL3641R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 175 kD Observed band size: 175 kD Sample: Cerebellum (Mouse) Lysate at 40 ug Primary: Anti- SUR1 (SL3641R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 175 kD Observed band size: 175 kD Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: Pancreas (Mouse) Lysate at 40 ug Lane 3: Stomach (Mouse) Lysate at 40 ug Lane 4: Cerebrum (Rat) Lysate at 40 ug Lane 5: SH-SY5Y (Human) Cell Lysate at 30 ug Primary: Anti-SUR1 (SL22836R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 177 kD Observed band size: 180 kD

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