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Product Name Plexin A2 Chinese Name 神经丛蛋白A2抗体 Alias PlexinA2; PLXA2; PLXNA2; Semaphorin receptor OCT. Research Area immunology Neurobiology The cell membrane受体 Cell Surface Molecule Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 205kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Plexin A2: 1251-1400/1894 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Plexin A2 is a coreceptor for SEMA3A and is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. This coreceptor plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin in which the plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Function:
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Subunit:
Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity).
Tissue Specificity:
Detected in fetal brain.
Similarity:
Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 1 Sema domain.
SWISS:
O75051
Gene ID:
5362
Database links:Entrez Gene: 5362 Human
Entrez Gene: 18845 Mouse
Omim: 601054 Human
SwissProt: O75051 Human
SwissProt: P70207 Mouse
Unigene: 497626 Human
Unigene: 2251 Mouse
Plexin A2蛋白是SEMA3A的辅助受体,Plexin A2蛋白在神经细胞轴突导向, 生长和细胞迁移中发挥作用。
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