Product Name	PRL3
Chinese Name	磷酸酯酶3蛋白抗体
Alias	PRL-R;Potentially prenylated protein tyrosine phosphatase; PRL 3; PRL R; PRLR: PRL3; PRLR; Protein tyrosine phosphatase 4a3; PTP 4A3: PTP4A3.
Research Area	Tumour  immunology  Signal transduction  transcriptional regulatory factor  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	19kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PRL3/PTP4A3: 101-173/173
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PTP4A3 protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. It enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. It may be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. PTP4A3 interacts with tubulin. It belongs to the protein tyrosine phosphatase family. It is mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. It is consistently overexpressed in colon cancer metastasis. Subunit: Interacts with tubulin. Subcellular Location: Cell membrane. Early endosome. Tissue Specificity: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. Similarity: Belongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain. SWISS: O75365 Gene ID: 11156 Database links: Entrez Gene: 11156 Human Entrez Gene: 19245 Mouse Entrez Gene: 362930 Rat Omim: 606449 Human SwissProt: O75365 Human SwissProt: Q9D658 Mouse SwissProt: Q78EG7 Rat Unigene: 43666 Human

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