Product Name	SLC40A1
Chinese Name	The cell membrane铁TransporterFP1抗体
Alias	Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST079; MSTP079; MTP1; SLC11A3.
literatures	Specific References  (3)     |     SL3579R has been referenced in 3 publications. [IF=5.279] Yuan Zhao. et al. Chlorogenic Acid Alleviates Chronic Stress-Induced Duodenal Ferroptosis via the Inhibition of the IL-6/JAK2/STAT3 Signaling Pathway in Rats. J AGR FOOD CHEM. J Agr Food Chem. 2022;XXXX(XXX):XXX-XXX  WB ;  Rat.   PubMed:35380825 [IF=4.255] Liu et al. Synthetic Porcine Hepcidin Exhibits Different Roles in Escherichia coli and Salmonella Infections. (2017) Antimicrob.Agents.Chemother.Sep 22;61(10).  WB ;  ETEC K88&Salmonella enterica serovar Typhimurium CMCC 50013.   PubMed:28760901 [IF=2.431] Zhang J et al. Iron Dyshomeostasis Participated in Rat Hippocampus Toxicity Caused by Aluminum Chloride. Biol Trace Elem Res. 2019 Dec 17.  WB ;  Rat.   PubMed:31848921
Research Area	Tumour  immunology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	63kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC40A1: 201-300/571
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin. Function: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Subcellular Location: Cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of polarized epithelial cells. Tissue Specificity: Expressed in placenta, intestine, muscle and spleen. DISEASE: Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Similarity: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. SWISS: Q9NP59 Gene ID: 30061 Database links: Entrez Gene: 30061 Human Entrez Gene: 53945 Mouse Entrez Gene: 170840 Rat Omim: 604653 Human SwissProt: Q9NP59 Human SwissProt: Q9JHI9 Mouse SwissProt: Q923U9 Rat Unigene: 643005 Human Unigene: 28756 Mouse Unigene: 15324 Rat
Product Picture	Sample: Embryo (Mouse) Lysate at 40 ug Primary: Anti-SLC40A1 (SL3579R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63 kD Observed band size: 63 kD

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