Product Name	Phospho-EEF2 (Thr57)
Chinese Name	磷酸化真核翻译延长因子2抗体
Alias	EEF2 (phospho T57); p-EEF2 (phospho T57); EEF2; EF2; Elongation factor 2; Eukaryotic translation elongation factor 2; Eukaryotic Elongation Factor-2; EF2_HUMAN; EF-2.
Product Type	Phosphorylated anti
Research Area	Tumour  Cell biology  immunology  Signal transduction  Apoptosis  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	95kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human EEF2 around the phosphorylation site of Thr56: RF(p-T)DT
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	EEF2 is a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylation by EF-2 kinase completely inactivates EF-2. Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis. ISGylated. Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. SWISS: P13639 Gene ID: 1938 Database links: Entrez Gene: 1938 Human Entrez Gene: 13629 Mouse Entrez Gene: 29565 Rat Omim: 130610 Human SwissProt: P13639 Human SwissProt: P58252 Mouse SwissProt: P05197 Rat Unigene: 515070 Human Unigene: 326799 Mouse Unigene: 379638 Mouse Unigene: 482883 Mouse Unigene: 55145 Rat

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