Product Name	Phospho-TBK1 (Ser172)
Chinese Name	磷酸化NF-κB活化激酶抗体
Alias	NAK (phospho S172); Phospho-TBK1/NAK (Ser172); P-TBK1(Ser172); p-NAK(Ser172); EC 2.7.11.1; FLJ11330; NAK; NF kappa B activating kinase; NF kB activating kinase; NF-kappa-B-activating kinase; Serine/threonine protein kinase TBK 1; Serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; TBK 1; TBK1_HUMAN.
literatures	Specific References  (3)     |     SL3440R has been referenced in 3 publications. [IF=12.12] Takahashi et al. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.Nat Commun. 2018 Mar 28;9(1):1249.  IF(ICC) ;  Mouse.   PubMed:29593264 [IF=5.834] Xuan Zhou. et al. The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta. FASEB J. 2023 Feb;37(3):e22806  IHC ;  Human.   PubMed:36786722 [IF=4.784] Wan B et al. Porcine FcγRIIb mediated PRRSV ADE infection through inhibiting IFN-β by cytoplasmic inhibitory signal transduction. Int J Biol Macromol. 2019 Jul 5;138:198-206.  WB ;  Monkey.   PubMed:31284005
Product Type	Phosphorylated anti
Research Area	Tumour  immunology  Signal transduction  Apoptosis  transcriptional regulatory factor  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	84kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human TBK1 around the phosphorylation site of Ser172: FV(p-S)LY
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021] Subunit: Self-associates. Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitous with higher expression in testis. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. Contains 1 protein kinase domain. Contains 1 ubiquitin-like domain. SWISS: Q9UHD2 Gene ID: 29110 Database links: Entrez Gene: 29110 Human Entrez Gene: 56480 Mouse Entrez Gene: 299827 Rat SwissProt: Q9UHD2 Human SwissProt: Q9WUN2 Mouse TBK1是NF-κB信号通道中的一种激酶，它是被KRAS-改变的细胞存活所必不可少的。TBK1诱导反凋亡信号，TBK1与NF-κB共同作用于KRAS介导的癌变过程中,可能是一个癌症治疗目标。
Product Picture	Sample: Lane 1: Human Raji cell lysates Lane 2: Human HeLa cell lysates Primary: Anti-Phospho-TBK1 (Ser172) (SL3440R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 84 kDa Observed band size: 84 kDa

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