Rabbit Anti-Phospho-SRF (Ser103)antibody
Serum Response Factor SRF (phospho S103); SRF (phospho Ser103); P-SRF (Ser103); ELK3 (phospho S103); p-ELK3 (phospho S103); c fos serum response element binding factor; Serum Response Factor SRF; c fos serum response element binding transcription factor;
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Product Name Phospho-SRF (Ser103) Chinese Name 磷酸化血清应答因子抗体 Alias Serum Response Factor SRF (phospho S103); SRF (phospho Ser103); P-SRF (Ser103); ELK3 (phospho S103); p-ELK3 (phospho S103); c fos serum response element binding factor; Serum Response Factor SRF; c fos serum response element binding transcription factor; ELK3; ERP; MCM 1; MCM-1; MCM1; OTTHUMP00000039820; SAP2; Serum response factor; SRF; SRF serum response factor c fos serum response element binding transcription factor; SRF_HUMAN. literatures Product Type Phosphorylated anti Research Area Tumour immunology Signal transduction transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 56kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated Synthesised phosphopeptide derived from human SRF around the phosphorylation site of Ser103: SL(p-S)E Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008].
Function:
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.
Subunit:
Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1. Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1. Forms a nuclear ternary complex with MKL1 and SCAI.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated by PRKDC.
Similarity:
Contains 1 MADS-box domain.
SWISS:
P31948
Gene ID:
6722
Database links:Entrez Gene: 6722 Human
Entrez Gene: 20807 Mouse
Omim: 600589 Human
SwissProt: P11831 Human
SwissProt: Q9JM73 Mouse
Unigene: 520140 Human
Unigene: 45044 Mouse
transcriptional regulatory factor（Transcriptin Regulators）
血清应答因子(SRF)是一种转录因子蛋白，可以结合启动子DNA序列中的血清应答元件(SRE)，调节一系列基因的表达，包括即刻早期基因的表达，如c-fos、fosB、junB、egr-1、egr-2，以及神经元基因nurr1、肌肉基因如肌动蛋白、肌球蛋白基因等.
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