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Product Name PANK1 Chinese Name 泛酸激酶1抗体 Alias coaA; hPanK; hPanK1; PANK; PANK1; PANK1_HUMAN; PANK1a; PANK1b; PanK1beta; Pantothenate kinase 1; Pantothenate kinase; Pantothenic acid kinase 1. Research Area Tumour Cardiovascular Cell biology immunology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, ) Applications WB=1:500 IHC-P=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 64kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PANK1 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA). Pantothenate kinase 1 (PANK1) is a 598 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localized to the cytoplasm, PANK1 is strongly inhibited by acetyl-CoA and manyl-CoA, as well as by high concentration of non-esterified CoA (CoASH). Four known isoforms of PANK1 exist as a result of alternative splicing events. Of these isoforms, PANK1a and PANK1b have been identified as the catalytically active isoforms. Isoform PANK1a is most highly expressed in brain, heart, kidney, liver, skeletal muscle and kidney. Isoform PANK1b is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.
Function:
Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Isoform 1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.
Similarity:
Belongs to the type II pantothenate kinase family.
SWISS:
Q8TE04
Gene ID:
53354
Database links:Entrez Gene: 53354 Human
Entrez Gene: 75735 Mouse
Omim: 606160 Human
SwissProt: Q8TE04 Human
SwissProt: Q8K4K6 Mouse
Unigene: 376351 Human
Unigene: 24742 Mouse
Unigene: 6581 Rat
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