Product Name	Phospho-NR1D1 (Ser55 + Ser59)
Chinese Name	磷酸化The nucleus受体Rev-Erbα抗体
Alias	NR1D1 (Phospho Ser55 + Ser59); NR1D1 (Phospho S55 + S59); EAR-1; EAR1; ERBA-RELATED 1; hRev; Nr1d1; NR1D1_HUMAN; Nuclear Receptor Rev-ErbA Alpha; Nuclear receptor subfamily 1 group D member 1; Orphan nuclear receptor NR1D1; Rev erbAalpha; Rev erbalpha; Rev-erbA-alpha; Rev-ErbAalpha; REV-ERBalpha; THRA1; THRAL; Thyroid hormone receptor alpha-like; Thyroid hormone receptor, alpha like; V-erbA related protein EAR-1; V-erbA-related protein 1.
Product Type	Phosphorylated anti
Research Area	Cell biology  immunology  Chromatin and nuclear signals  Neurobiology  Signal transduction  Growth factors and hormones  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	67kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human REV-ERB alpha around the phosphorylation site of Ser55/59: PP(p-S)PTG(p-S)LT
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	NR1D1, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha). NR1D1 is a target of Nuclear Receptor ROR Alpha and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism. Mice lacking NR1D1 show abnormal postnatal cerebellar development. NR1D1 expression has been documented in human skeletal muscle and a variety of mouse and rat tissues. ESTs have been isolated from human tissue libraries, including cancerous adrenal, blood, brain, breast, colon, duodenum, fetus, head/neck, kidney, lung, skeletal muscle, skin, synovium, uterus, normal brain, breast, colon, eye, heart, pancreas, pituitary, prostate, skeletal muscle, skin, testis and thyroid. Function: Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription. Possible receptor for triiodothyronine. Subunit: Interacts with C1D and NR2E3. Interacts with SP1. Subcellular Location: Nucleus (Potential). Tissue Specificity: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P20393 Gene ID: 9572 Database links: Entrez Gene: 768225 Cow Entrez Gene: 9572 Human Entrez Gene: 217166 Mouse Entrez Gene: 252917 Rat Omim: 602408 Human SwissProt: Q08E02 Cow SwissProt: P20393 Human SwissProt: Q3UV55 Mouse SwissProt: Q63503 Rat Unigene: 592130 Human Unigene: 724 Human Unigene: 390397 Mouse Unigene: 29848 Rat 1.The nucleus受体Rev-Erbα是生物钟系统的重要组成部分,不仅是生物钟基因而且是生物钟调节基因,在维持生物节律准确性中发挥着重要作用； 2.Rev-Erbα调节糖代谢、脂质代谢、脂肪形成、纤溶蛋白降解、血管炎症并与其他能量平衡相关核受体相互作用。
Product Picture	Tissue/cell: human laryngeal tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Phospho-NR1D1 (Ser55 + Ser59) Polyclonal Antibody, Unconjugated(SL3386R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human laryngeal tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Phospho-NR1D1 (Ser55 + Ser59) Polyclonal Antibody, Unconjugated(SL3386R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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