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Product Name Phospho-HSL (Ser660) Chinese Name 磷酸化荷尔蒙敏感脂肪酶抗体 Alias Hormone sensitive lipase; Hormone sensitive lipase testicular isoform; HSL; LHS; Lipase hormone sensitive; LIPE. literatures Specific References (1) | SL3358R has been referenced in 1 publications.[IF=4.486] Chengqian Li. et al. Mutation of the novel acetylation site at K414R of BECN1 is involved in adipocyte differentiation and lipolysis. 2021 Jun 04 WB ; Human.Product Type Phosphorylated anti Research Area Cardiovascular immunology Signal transduction Growth factors and hormones transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 83kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from mouse HSL around the phosphorylation site of Ser660: SK(p-S)HE Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Subcellular Location:
Cell membrane. Membrane, caveola. Cytoplasm,bcytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.
Post-translational modifications:
Phosphorylation by AMPK may block translocation to lipid droplets.
Similarity:
Belongs to the 'GDXG' lipolytic enzyme family.
SWISS:
P54310
Gene ID:
16890
Database links:Entrez Gene: 3991 Human
Entrez Gene: 16890 Mouse
Omim: 151750 Human
SwissProt: Q05469 Human
SwissProt: Q6NSL7 Human
SwissProt: P54310 Mouse
Unigene: 656980 Human
Unigene: 158548 Mouse
Unigene: 333679 Mouse
Unigene: 10566 Rat
HSL又称:敏感性甘油三酯脂肪酶,在脂肪动员中,脂肪细胞内激素敏感性甘油三酯脂肪酶(HSL)起决定性作用,它是脂肪分解的限速酶,称为激素敏感性脂肪酶。肾上腺素、去甲肾上腺素、胰高血糖素等激活HSL促进脂肪动员;胰岛素,前列腺素E及烟酸等抑制HSL,抑制脂肪的动员。
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