Product Name	Phospho-Nur77 (Ser351)
Chinese Name	磷酸化孤儿核受体蛋白Nur77抗体
Alias	NR4A1(phospho S351); NUR77 (phospho S351); p-NUR77 (phospho S351); GFRP 1; GFRP; GFRP1; Growth factor inducible nuclear protein N10; Growth Factor Inducible Nuclear Protein NP10; Growth Factor Response Protein 1; Hbr1; HMR; Hormone Receptor; MGC9485; N10; N10 nuclear protein; NAK 1; NAK1; NGFIB; NP 10; NP10; NR4A1; Nuclear hormone receptor NUR/77; Nuclear Hormone Receptor TR3; Nuclear Receptor Subfamily 4 Group A Member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor NR4A1; ST 59; ST59; Steroid receptor TR3; TR 3; TR3; TR3 orphan receptor; Early response protein NAK1.
Product Type	Phosphorylated anti
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Chromatin and nuclear signals  Neurobiology  Signal transduction  Apoptosis  transcriptional regulatory factor  Diabetes
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	66kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human Nur77 around the phosphorylation site of Ser351: LP(p-S)KP
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Subunit: Binds DNA as a monomer. Interacts with GADD45GIP1. Subcellular Location: Nucleus. Tissue Specificity: Fetal muscle and adult liver, brain and thyroid. Post-translational modifications: Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P22736 Gene ID: 3164 Database links: Entrez Gene: 3164 Human Entrez Gene: 15370 Mouse Entrez Gene: 79240 Rat Omim: 139139 Human SwissProt: P22736 Human SwissProt: P12813 Mouse SwissProt: P22829 Rat Unigene: 524430 Human Unigene: 119 Mouse Unigene: 10000 Rat 孤儿核受体蛋白Nur77是早期反应转录因子之一，多种刺激因子如缺氧可诱导其迅速表达，Nur77参与调控细胞增殖、存活、分化等过程。这类核受体是体内广泛分布的配体依赖性的转录因子，通过调控基因协调表达，在机体的生长发育、The new supersedes the old，Cell differentiation及体内许多生长发育过程中发挥重要作用，其功能障碍将导致一系列疾病的发生，如；癌症、Diabetes、肥胖、不孕不育等等。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phospho-Nur77(Ser351)) Polyclonal Antibody, Unconjugated (SL3313R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining.

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