Product Name	Phospho-HSL (Ser959 + Ser960)
Chinese Name	磷酸化荷尔蒙敏感脂肪酶抗体
Alias	HSL (Phospho-Ser959 + Ser960); HSL (Phospho S959 + S960); Hormone sensitive lipase; Hormone sensitive lipase testicular isoform; HSL; LHS; Lipase hormone sensitive; LIPE; LIPS_HUMAN.
Product Type	Phosphorylated anti
Research Area	Cardiovascular  immunology  Growth factors and hormones  Kinases and Phosphatases  Diabetes
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Horse, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	117kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from rat HSL around the phosphorylation site of Ser959/960: RR(p-S)(p-S)-NH2
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008] Function: In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Subcellular Location: Cell membrane. Membrane, caveola. Cytoplasm,bcytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. Post-translational modifications: Phosphorylation by AMPK may block translocation to lipid droplets. Similarity: Belongs to the 'GDXG' lipolytic enzyme family. SWISS: P15304 Gene ID: 25330 Database links: Entrez Gene: 3991 Human Entrez Gene: 16890 Mouse Entrez Gene: 25330 Rat Omim: 151750 Human SwissProt: Q05469 Human SwissProt: Q6NSL7 Human SwissProt: P54310 Mouse SwissProt: P15304 Rat Unigene: 656980 Human Unigene: 158548 Mouse Unigene: 333679 Mouse Unigene: 10566 Rat HSL又称：敏感性甘油三酯脂肪酶，在脂肪动员中，脂肪细胞内激素敏感性甘油三酯脂肪酶（HSL）起决定性作用，它是脂肪分解的限速酶，称为激素敏感性脂肪酶。 肾上腺素、去甲肾上腺素、胰高血糖素等激活HSL促进脂肪动员；胰岛素，前列腺素E及烟酸等抑制HSL，抑制脂肪的动员。分子量：116KDa

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