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Product Name Phospho-IKB beta (Ser23) Chinese Name 磷酸化KB抑制蛋白β抗体 Alias IkB beta (phospho S23); p-IkB beta (phospho S23); IKB beta (Phospho-Ser23); IKB beta (Phospho-S23); p-IKB beta (Ser23); p-IKB beta (S23); phospho-NFKBIB(Ser23); NFKBIB(phospho S23); IkB-beta(Phospho-Ser22); IkB beta; NF-kappa-B inhibitor beta; IKB beta; NF-kappa-BIB; TRIP-9; I-kappa-B-beta; IkappaBbeta; IkB-beta; IkB-B; Thyroid receptor-interacting protein 9; TR-interacting protein 9; NFKBIB; IKBB. literatures Specific References (4) | SL3191R has been referenced in 4 publications.[IF=7.59] Muzhe Li. et al. STS load PCL- MECM based hydrogel hybrid scaffold promote meniscal regeneration via modulating macrophage phenotype polarization. BIOMATER SCI-UK. 2023 Jan;: WB ; Rabbit.[IF=4.493] Chen Xiu-min. et al. Chinese Herbal Formula Huayu-Qiangshen-Tongbi Decoction Attenuates Rheumatoid Arthritis through Upregulating miR-125b to Suppress NF-κB-Induced Inflammation by Targeting CK2. J IMMUNOL RES. 2022;2022:2836128 WB ; Human.[IF=3.076] Sogorkova,et al.Optimization of cell growth on palmitoyl-hyaluronan knitted scaffolds developed for tissue engineering applications.(2018) Journal of Biomedical Materials Research. Part A. 106:1488-1499. IF(ICC) ; Human.[IF=1.895] Lin,et al.The CXCL12/CXCR4 axis promotes migration, invasion and EMT in human papillary thyroid carcinoma B-CPAP cells via NF-κB signaling.(2018) Biochemistry and Cell Biology. :. WB ; Human.Product Type Phosphorylated anti Research Area Tumour immunology Signal transduction Growth factors and hormones transcriptional regulatory factor Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 39kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human NFKBIB around the phosphorylation site of Ser23: LG(p-S)LG Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011].
Function:
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Subunit:
Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Expressed in all tissues examined.
Post-translational modifications:
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
Similarity:
Belongs to the NF-kappa-B inhibitor family.
Contains 6 ANK repeats.
SWISS:
Q15653
Gene ID:
4793
Database links:Entrez Gene: 4793 Human
Entrez Gene: 18036 Mouse
Omim: 604495 Human
SwissProt: Q15653 Human
SwissProt: Q60778 Mouse
Unigene: 9731 Human
Unigene: 220333 Mouse
Unigene: 8395 Rat
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