Product Name	Phospho-Dab1 (Tyr232)
Chinese Name	磷酸化Disabled 1抗体
Alias	Dab1 (phospho Y232); Dab1 (phospho Tyr232); p-Dab1 (phospho Y232); Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari; Dab, reelin signal transducer, homolog 1 (Drosophila); Dab1; DAB1_HUMAN.
Product Type	Phosphorylated anti
Research Area	Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	65kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human Dab1 around the phosphorylation site of Tyr232: GV(p-Y)DV
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity. Subunit: Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1. Interacts with LRP1. Post-translational modifications: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling. Similarity: Contains 1 PID domain. SWISS: O75553 Gene ID: 1600 Database links: Entrez Gene: 374083 Chicken Entrez Gene: 1600 Human Entrez Gene: 13131 Mouse Entrez Gene: 266729 Rat Entrez Gene: 692351 Zebrafish Omim: 603448 Human SwissProt: O75553 Human SwissProt: P97318 Mouse SwissProt: Q8CJH2 Rat Unigene: 477370 Human Unigene: 289682 Mouse Unigene: 206534 Rat
Product Picture	Sample: U87MG(Human) Cell Lysate at 30 ug Primary: Anti-Phospho-Dab1 (Tyr232) (SL3115R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kD Observed band size: 65 kD

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