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Product Name phospho-PLB (Ser16) Chinese Name 磷酸化心脏磷蛋白抗体 Alias Phospholamban (phospho S16); p-Phospholamban (phospho S16); p-PLB(S16); Cardiac phospholamban; CMD1P; PLB; PLN; PPLA_HUMAN. Product Type Phosphorylated anti Research Area Cardiovascular immunology Signal transduction transcriptional regulatory factor Channel protein Cell Surface Molecule Mitochondrion Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 5.7kDa Cellular localization cytoplasmic The cell membrane Mitochondrion Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human Cardiac phospholamban around the phosphorylation site of Ser16: RA(p-S)TI Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) . Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) . CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Function:
Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
Subunit:
Homopentamer. Interacts with HAX1.
Subcellular Location:
Mitochondrion membrane; Single-pass membrane protein. Sarcoplasmic reticulum.
Tissue Specificity:
Heart.
Post-translational modifications:
Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
DISEASE:
[DISEASE] Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
[DISEASE] Defects in PLN are the cause of familial hypertrophic cardiomyopathy type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Similarity:
Belongs to the phospholamban family.
SWISS:
P26678
Gene ID:
5350
Database links:Entrez Gene: 5350 Human
Entrez Gene: 18821 Mouse
Omim: 172405 Human
SwissProt: P26677 Chicken
SwissProt: P26678 Human
SwissProt: P61014 Mouse
SwissProt: P61015 Rabbit
Unigene: 170839 Human
Unigene: 745010 Human
Unigene: 34145 Mouse
Unigene: 9740 Rat
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