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Product Name SPHK2 Chinese Name 鞘氨醇激酶2抗体 Alias sphingosine kinase 2; SK 2; SPK 2; C76851; MGC102297; SPHK2_HUMAN. Research Area Cell biology Signal transduction Apoptosis Kinases and Phosphatases Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, ) Applications ELISA=1:5000-10000 ICC=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 72kDa Cellular localization The nucleus cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SPHK2 : 101-200/654 Lsotype IgG Purification affinity purified by Protein A Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
SWISS:
Q9NRA0
Gene ID:
56848
Database links:Entrez Gene: 56848 Human
Entrez Gene: 56632 Mouse
Omim: 607092 Human
SwissProt: Q9NRA0 Human
SwissProt: Q9JIA7 Mouse
Unigene: 528006 Human
Unigene: 24222 Mouse
Product Picture SH-SY5Y cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (SPHK2) polyclonal Antibody, Unconjugated (SL2653R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.
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