Product Name	RGS5
Chinese Name	G protein signal转导调节因子5抗体
Alias	MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129; Regulator of G Protein Signalling 5; RGS 5; RGS5_HUMAN.
Research Area	Tumour  Cell biology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse RGS5: 81-181/181
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. RGS5 seems to be an important signalling regulator in the vascular system. Present data suggest that RGS5 may be involved in the regulation of capillary growth, angiogenesis, and in the pathophysiology of stroke. Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Subcellular Location: Isoform 1: Cytoplasm，Membrane. Isoform 2: Cytoplasm. Similarity: Contains 1 RGS domain. SWISS: O08850 Gene ID: 19737 Database links: Entrez Gene: 8490 Human Entrez Gene: 19737 Mouse Entrez Gene: 54294 Rat Omim: 603276 Human SwissProt: O15539 Human SwissProt: O08850 Mouse SwissProt: Q864Z2 Pig SwissProt: P49800 Rat Unigene: 24950 Human Unigene: 20954 Mouse Unigene: 1150 Rat RGS5是调控G-蛋白活性的信号蛋白（RGS）家族的一员，是Tumour血管形成的一个重要调控因子.主要与G蛋白α亚基结合，发挥GTP酶激活蛋白（GAPs）作用，负性调节G protein signal传导途径。Rgs5在体内多个器官都有表达，主要表达于这些组织器官的血管周细胞。 近期发现，Rgs5与血管的生成、发展及成熟有密切关系，影响全身各系统功能。同时在一些Tumour组织和细胞中也有高表达，且与Tumour血管的异常有关。Rgs5基因的缺失可以使得Tumour血管正常化，并促进免疫治疗的效果，提示其可能成为抗Tumour血管治疗的新靶点。另外RGS5也可能是一种Tumour相关抗原．对Tumour诊断及治疗有着积极的意义．
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RGS5) Polyclonal Antibody, Unconjugated (SL2794R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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