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Product Name CRHR2 Chinese Name 促肾上腺皮质释放激素受体2抗体 Alias Corticotropin releasing hormone receptor 2; Corticotropin Releasing Factor Receptor 2; Corticotropin-releasing hormone receptor 2; Corticotropin-releasing factor receptor 2; CRF 2; CRF 2R; CRF R2; CRF2; CRF2R; CRFR 2; CRFR2; CRH 2R; CRH R2; CRH2R; CRHR 2; CRHR2; CRHRⅡ. literatures Specific References (1) | SL2792R has been referenced in 1 publications.[IF=3.671] Fan,et al.Antitumor activity and underlying mechanism of Sargassum fusiforme polysaccharides in CNE-bearing mice.(2018) International Journal of Biological Macromolecules. 112:516-522. Other ; Mouse.Research Area immunology Neurobiology G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 43kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CRHR2: 51-150/411 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
Function:
This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subunit:
Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 2 family.
SWISS:
Q13324
Gene ID:
1395
Database links:Entrez Gene: 1395 Human
Entrez Gene: 12922 Mouse
Omim: 602034 Human
SwissProt: Q13324 Human
SwissProt: Q60748 Mouse
Unigene: 546246 Human
Unigene: 236081 Mouse
Unigene: 10023 Rat
Product Picture Sample:
Lane 1: Human Hela cell lysates
Lane 2: Human 293T cell lysates
Lane 3: Human HL60 cell lysates
Primary: Anti-CRHR2 (SL2792R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kD
Observed band size: 52 kD
Sample:
Brain (Mouse) Lysate at 40 ug
Cerebellum (Mouse) Lysate at 40 ug
Kidney (Mouse) Lysate at 40 ug
Heart (Mouse) Lysate at 40 ug
Muscle (Mouse) Lysate at 40 ug
Primary: Anti-CRHR2 (SL2792R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 43 kD
Observed band size: 50 kD
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