Product Name	Urocortin 3
Chinese Name	尿皮质素UCN3抗体
Alias	SCP; SPC; Stresscopin; Ucn III; UCN3; UCN3 urocortin 3 stresscopin; UCNIII; Urocortin 3 stresscopin; Urocortin III; UCN3_HUMAN.
literatures	Specific References  (3)     |     SL2786R has been referenced in 3 publications. [IF=5.717] Sina Kavalakatt. et al. Urocortin Neuropeptide Levels Are Impaired in the PBMCs of Overweight Children. Nutrients. 2022 Jan;14(3):429  WB ;  Human.   PubMed:10.3390/nu14030429 [IF=4.379] Kavalakatt, Sina. et al. Urocortin 3 overexpression reduces ER stress and heat shock response in 3T3-L1 adipocytes. Sci Rep-Uk. 2021 Aug;11(1):1-11  WB ;  Mouse.   PubMed:34341463 [IF=4.27] Ouaamari et al. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. (2015) J.Proteome.Re. 14:3111-22  WB ;  Mouse.   PubMed:26151086
Research Area	Tumour  Cardiovascular  Cell biology  Neurobiology  Growth factors and hormones  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:200-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	4/18kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human UCN3: 120-157/161
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Urocortin 3 is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. A powerful cytoprotective effect of urocortin peptide administration against ischemia and reperfusion injury has been demonstrated in isolated cardiomyocyte models, as well as in the intact heart both in vitro and in vivo. Function: Urocortin 3 is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. A powerful cytoprotective effect of urocortin peptide administration against ischemia and reperfusion injury has been demonstrated in isolated cardiomyocyte models, as well as in the intact heart both in vitro and in vivo. Subunit: Binds with high affinity to CRF receptors 2-alpha and 2-beta. Subcellular Location: Secreted. Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. SWISS: Q969E3 Gene ID: 114131 Database links: Entrez Gene: 114131 Human Omim: 605901 Human SwissProt: Q969E3 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Urocortin 3) Polyclonal Antibody, Unconjugated (SL2786R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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