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Product Name BRINP1 Chinese Name 膀胱癌缺失基因1抗体 Alias Deleted in bladder cancer protein 1; deleted in bladder cancer protein 1 precursor; IB3089A; DBC1; DBCCR1; FAM5A; deleted in bladder cancer protein 1 homolog precursor; BMP/retinoic acid-inducible neural-specific protein 1; BRINP; Brinp1; LOC140610; DBC 1; DBC.1; DBCCR1; Deleted in bladder cancer chromosome region candidate 1; Deleted in breast cancer 1; Deleted in breast cancer gene 1 protein; FAM5A; KIAA1967; OTTHUMP00000022751; p30 DBC; p30 DBC protein; Protein FAM5A; DBC1_HUMAN. Research Area Tumour Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Chicken, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 86kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human DBC1: 101-200/761 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq].
Function:
Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.
Similarity:
Belongs to the FAM5 family.
Contains 1 MACPF domain.
SWISS:
O60477
Gene ID:
1620
Database links:Entrez Gene: 1620 Human
Entrez Gene: 56710 Mouse
Omim: 602865 Human
SwissProt: O60477 Human
SwissProt: Q920P3 Mouse
Product Picture Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DBC1) Polyclonal Antibody, Unconjugated (SL2761R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DBC1) Polyclonal Antibody, Unconjugated (SL2761R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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