Product Name	DKK3
Chinese Name	抑癌蛋白DKK3抗体
Alias	Dickkopf 3; Dickkopf homolog 3; Dickkopf related protein 3; Dickkopf related protein 3 Precursor; Dickkopf3; DKK 3; DKK3; hDkk 3; hDkk3; REIC; RIG-like 5-6; RIG-like 7-1; DKK3_HUMAN; Dickkopf 3 homolog (Xenopus laevis); Dickkopf homolog 3; Dickkopf-3; Dickkopf-related protein 3; Dkk-3; hDkk-3; Regulated in glioma; RIG.
literatures	Specific References  (2)     |     SL2686R has been referenced in 2 publications. [IF=1.922] Cao et al. Dickkopf‑3 upregulation mediates the cardioprotective effects of curcumin on chronic heart failure. (2018) Mol.Med.Rep. 17:7249-7257  WB ;  rabbit.   PubMed:29568962 [IF=0.88] Ning, Shujie, et al. "Effect of autonomic nerves on Dickkopf-3 expression in the uterus during early pregnancy of rats."Animal Biology(2015).  IHC-P ;  Rat.   PubMed:10.1163/15707563-00002474
Research Area	Tumour  Cell biology  immunology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DKK3: 31-130/350
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Dickkopf 3, like DKK1, DKK2, and DKK4, possesses an N terminal signal peptide and 2 conserved cysteine rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin type proteases. Subunit: Interacts with LRP5 and LRP6. Subcellular Location: Secreted. Tissue Specificity: Highest expression in heart, brain, and spinal cord. Similarity: Belongs to the dickkopf family. SWISS: Q9UBP4 Gene ID: 27122 Database links: Entrez Gene: 27122 Human NCBI: 40548393 Human Omim: 605416 Human SwissProt: Q9UBP4 Human Unigene: 292156 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DKK3) Polyclonal Antibody, Unconjugated (SL2686R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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