Product Name	NFAM1
Chinese Name	NFAM1抗体
Alias	NFAT activation molecule 1 precursor; NFAT activation molecule 1 precursor; Calcinerin/NFAT activating ITAM containing protein; CNAIP; NFAT activation molecule 1; Calcineurin/NFAT-activating ITAM-containing protein; NFAT-activating protein with ITAM motif 1; NFAM1_HUMAN.
literatures	Specific References  (2)     |     SL2680R has been referenced in 2 publications. [IF=6.543] Zhu Jianbing. et al. Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1. OXID MED CELL LONGEV. 2022;2022:8392313  WB ;  Human.   PubMed:35615580 [IF=4.14] Sambandam et al. NFAM1 signaling enhances osteoclast formation and bone resorption activity in Paget's disease of bone. (2017) Bone. 101:236-244  WB ;  Rat.   PubMed:28506889
Research Area	immunology  Chromatin and nuclear signals  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	30kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NFAM1: 81-180/270 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	NFAM1 activates cytokine gene promoters such as the IL13 and TNF-alpha promoters. It contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. Function: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. Subunit: Interacts with ZAP70 and SYK. No direct interaction with the B-cell antigen receptor (BCR). Subcellular Location: Cell membrane; Single-pass type I membrane protein. Note=Partially recruited to lipid rafts upon BCR stimulation. Tissue Specificity: Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T cells, and lung. Expressed at low level in non-immune tissue. Post-translational modifications: N-glycosylated. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 1 ITAM domain. SWISS: Q8NET5 Gene ID: 150372 Database links: Entrez Gene: 150372 Human Omim: 608740 Human SwissProt: Q8NET5 Human Unigene: 436677 Human
Product Picture	Blank control:U937. Primary Antibody (green line): Rabbit Anti-NFAM1 antibody (SL2680R) Dilution: 1ug/Test; Secondary Antibody : Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. Blank control:U937. Primary Antibody (green line): Rabbit Anti-NFAM1 antibody (SL2680R) Dilution: 1ug/Test; Secondary Antibody : Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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