Product Name	Bone sialoprotein
Chinese Name	骨涎蛋白抗体
Alias	BNSP; Bone sialoprotein II; BSP; BSPII; Cell binding sialoprotein; Integrin binding sialoprotein; SPII; SIAL_HUMAN; Bone sialoprotein 2; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein.
literatures	Specific References  (6)     |     SL2668R has been referenced in 6 publications. [IF=6.344] Zheng, Han. et al. miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition. Int J Oral Sci. 2021 Dec;13(1):1-10  WB ;  Human.   PubMed:34876565 [IF=5.37] Yang, Zhenhua, et al. "Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a β-catenin-dependent manner." Molecular and Cellular Biology (2013): MCB-00456.  Mouse.   PubMed:24081330 [IF=4.963] Shi R et al. Analysis of the characteristics and expression profiles of coding and noncoding RNAs of human dental pulp stem cells in hypoxic conditions.Stem Cell Res Ther. 2019 Mar 12;10(1):89.  WB ;  Human.   PubMed:30867055 [IF=3.23] Potter AS, Potter SS (2015) Molecular Anatomy of Palate Development. PLoS ONE 10(7): e0132662. doi:10.1371  IHC-P ;  Mouse.   PubMed:26168040 [IF=3.078] Jilong Zou. et al. Resveratrol Benefits the Lineage Commitment of BMSCs into Osteoblasts via MiR‐320c by Targeting Runx2. 2021 Jan 22  WB ;  Human.   PubMed:33481337 [IF=2.677] Xing Yifeng. et al. Osteogenic effects of rapamycin on bone marrow mesenchymal stem cells via inducing autophagy. J ORTHOP SURG RES. 2023 Dec;18(1):1-13  WB ;  Rat.   PubMed:36814286
Research Area	Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Bone sialoprotein II: 21-120/317
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008] Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. Subcellular Location: Secreted. Post-translational modifications: N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains. Sulfated on either Tyr-320 or Tyr-321 (By similarity). SWISS: P21815 Gene ID: 3381 Database links: Entrez Gene: 3381 Human Entrez Gene: 15891 Mouse Entrez Gene: 24477 Rat Omim: 147563 Human SwissProt: P21815 Human SwissProt: Q61711 Mouse SwissProt: P13839 Rat Unigene: 518726 Human Unigene: 4987 Mouse Unigene: 9721 Rat
Product Picture	Sample: Lane 1: Bone (Mouse) Lysate at 40 ug Lane 2: Bone (Rat) Lysate at 40 ug Primary: Anti-Bone sialoprotein (SL2668R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34 kD Observed band size: 35 kD

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