Product Name	IL21
Chinese Name	白介素21抗体
Alias	Interleukin 21; Interleukin21; IL 21; IL-21; Za11; Interleukin-21; interleukin-21 isoform; IL21_HUMAN.
literatures	Specific References  (3)     |     SL2621R has been referenced in 3 publications. [IF=3.06] Guan, Li-juan, et al. "Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease." Cytokine 72.2 (2015): 160-165.  IHC-P ;  Human.   PubMed:25647271 [IF=1.26] Gong, Qiaoqiao, et al. "Increased levels of CCR7 (lo) PD‑1 (hi) CXCR5+ CD4+ T cells, and associated factors Bcl‑6, CXCR5, IL‑21 and IL‑6 contribute to repeated implantation failure." Experimental and Therapeutic Medicine 14.6 (2017): 5931-5941.  IHC-P ;  Human.   PubMed:29285142 [IF=1.26] Ma et al. Effect of follicular helper T cells on the pathogenesis of asthma. (2017) Exp.Ther.Me. 14:967-972  IHC-P ;  Mouse.   PubMed:28810548
Research Area	Tumour  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	18kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-21: 65-155/155
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Subcellular Location: Secreted. Tissue Specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. Similarity: Belongs to the IL-15/IL-21 family. SWISS: Q9HBE4 Gene ID: 59067 Database links: Entrez Gene: 378475 Cow Entrez Gene: 59067 Human Entrez Gene: 60505 Mouse Omim: 605384 Human SwissProt: Q76LU5 Cow SwissProt: Q9HBE4 Human SwissProt: Q9ES17 Mouse Unigene: 567559 Human Unigene: 157689 Mouse 白介素21是多效免疫调节活性的cell factor,与其受体结合后可以调节并促进B细胞、T细胞、NK细胞的增殖、分化并提高NK细胞杀伤活性。

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