Product Name	IL18R Beta
Chinese Name	白细胞介素-18受体β链抗体
Alias	IL-18R Beta; Interleukin-18 receptor beta; Accessory protein like; IL18R Beta; AcPL; IL 18RacP; IL 1R accessor protein like; IL 1R7; IL 1RacPL; IL18Rbeta; Interleukin 18 receptor accessory protein; IL18RAP; Interleukin-18 receptor accessory protein-like; IL-18R-beta; IL-18Rbeta; Accessory protein-like; AcPL; Interleukin-1 receptor 7; IL-1R-7; IL-1R7; CD218 antigen-like family member B; CD218b; I18RA_HUMAN.
literatures	Specific References  (3)     |     SL2616R has been referenced in 3 publications. [IF=4.3] Valente, Anthony J., et al. "Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin." Cellular Signalling (2013).  IP ;  Human.   PubMed:23541442 [IF=3.487] Valente et al. Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. (2013) Cell.Signal. 25:1447-56  IP,WB ;  Human.   PubMed:23541442 [IF=2.903] Dou Y et al. The Riemerella anatipestifer M949_RS01035 gene is involved in bacterial lipopolysaccharide biosynthesis. Vet. Res. (2018) Sep 17 ;49(1)  IP,WB ;  Human.   PubMed:30223890
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	68kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-18R beta: 15-120/599 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	IL18R Beta is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and IL18R Beta is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. Function: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Subunit: Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. Similarity: Belongs to the interleukin-1 receptor family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain. SWISS: O95256 Gene ID: 8807 Database links: Entrez Gene: 8807 Human Entrez Gene: 16174 Mouse Omim: 604509 Human SwissProt: O95256 Human SwissProt: Q9Z2B1 Mouse Unigene: 158315 Human Unigene: 20466 Mouse Unigene: 392521 Mouse
Product Picture	Sample:Spleen (Mouse)Lysate at 40 ug Primary: Anti-IL18R Beta(SL2616R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 68kD Observed band size: 68kD Sample: Lane 1: Human U937 cell lysates Lane 2: Human HL60 cell lysates Lane 3: Human A549 cell lysates Lane 4: Human Du145 cell lysates Primary: Anti- IL18R Beta (SL2616R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 68 kD Observed band size: 66 kD

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