Product Name	IL12RB2
Chinese Name	白细胞介素-12受体β2抗体
Alias	Interleukin-12 receptor subunit beta-2; RP11-102M16.1; IL12 receptor beta 2; IL12R beta2; Interleukin 12 receptor beta 2; Interleukin 12 receptor beta 2 chain; RP11 102M16.1.
literatures	Specific References  (4)     |     SL2604R has been referenced in 4 publications. [IF=4.433] Jose Rosas Almanza. et al. IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury. J NEUROSCI RES. 2022 Sep;:  IF ;  Mouse.   PubMed:36089917 [IF=3.293] Yusong Miao. et al. Mycoplasma gallisepticum induced inflammation-mediated Th1/Th2 immune imbalance via JAK/STAT signaling pathway in chicken trachea: Involvement of respiratory microbiota. Vet Microbiol. 2022 Feb;265:109330  WB ;  Chicken.   PubMed:34995932 [IF=2.87] Filková, Mária, et al. "Pro-inflammatory effects of interleukin-35 in rheumatoid arthritis." Cytokine 73.1 (2015): 36-43.  IHC-P ;  Human.   PubMed:25697137 [IF=0] Li R et al. Osteogenic Effects of IL-12 on Bone Marrow Mesenchymal Stem Cells Facilitates Its Irradiation Hematopoiesis Recovery. 14 January 2020, PREPRINT (Version 1) available at Research Square  WB ;  Mouse.   PubMed:DOI:10.21203/rs.2.20812/v1
Research Area	immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	95kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-12RB2: 301-400/862 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]. Function: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Subcellular Location: Membrane; Single pass type I membrane protein. Tissue Specificity: Isoform 2 is expressed at similar levels in both naive and activated T-cells. Post-translational modifications: On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains. SWISS: Q99665 Gene ID: 3595 Database links: Entrez Gene: 282452 Cow Entrez Gene: 489550 Dog Entrez Gene: 100722774 Guinea pig Entrez Gene: 3595 Human Entrez Gene: 16162 Mouse Entrez Gene: 397178 Pig Entrez Gene: 100350416 Rabbit Entrez Gene: 171334 Rat Entrez Gene: 100820736 Sheep Omim: 601642 Human SwissProt: Q99665 Human SwissProt: P97378 Mouse Unigene: 479347 Human Unigene: 188337 Mouse Unigene: 207395 Rat
Product Picture	Sample: Lane 1: Human A549 cell lysates Lane 2: Human Hela cell lysates Primary: Anti-IL12RB2 (SL2604R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 95 kDa Observed band size: 100 kDa

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