Product Name	DDB1
Chinese Name	DNA损伤Binding protein1抗体
Alias	DNA damage-binding protein 1; DDB1; DDB-1; ;Damage specific DNA binding protein 1; DDB 1; DDB p127 subunit; DDBa; DNA damage binding protein 1; UV damaged DNA binding factor; UV damaged DNA binding protein 1; UV DDB 1; UV-DDB1; X associated protein 1; XAP 1; XAP1; Xeroderma pigmentosum group E complementing protein; XPCE; XPE; XPE binding factor; XPE-BF.
Research Area	Tumour  immunology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	125kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DDB1: 951-1140/1140
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. [provided by RefSeq]. Subunit: Component of the UV-DDB complex which includes DDB1 and DDB2. Subcellular Location: Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage. Similarity: Belongs to the DDB1 family. SWISS: Q16531 Gene ID: 1642 Database links: Entrez Gene: 511951 Cow Entrez Gene: 100290337 Human Entrez Gene: 1642 Human Entrez Gene: 13194 Mouse Entrez Gene: 64470 Rat Omim: 600045 Human SwissProt: A1A4K3 Cow SwissProt: Q16531 Human SwissProt: Q3U1J4 Mouse SwissProt: Q9ESW0 Rat Unigene: 290758 Human Unigene: 289915 Mouse Unigene: 466856 Mouse Unigene: 8402 Rat

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