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Product Name FOXF1 Chinese Name 叉头蛋白F1抗体 Alias AI450827; FKH L5; FKHL 5; FKHL5; FKHL5; Forkhead (Drosophila) like 5; forkhead (Drosophila)-like 5; forkhead (Drosophila)-like 5; forkhead box F1; forkhead box F1; Forkhead box protein F1; Forkhead drosophila homolog like 5; Forkhead like 5; Forkhead related activator 1; Forkhead related protein FKHL5; Forkhead related transcription factor 1; forkhead-related activator 1; forkhead-related activator 1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1; FOX F1; FOXF 1; foxf1; FOXF1_HUMAN; FREAC 1; FREAC-1; FREAC1; FREAC1; HFH 8; homolog-like 5; homolog-like 5; MGC105125. Research Area immunology Chromatin and nuclear signals Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Chicken, Dog, Cow, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 40kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FOXF1: 285-379/379 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
Function:
Probable transcription activator for a number of lung-specific genes.
Subcellular Location:
Nucleus (Probable).
Tissue Specificity:
Expressed in lung and placenta.
DISEASE:
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]: A rare developmental disorder characterized by abnormal development of the capillary vascular system in the lungs. Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Contains 1 fork-head DNA-binding domain.
SWISS:
Q12946
Gene ID:
2294
Database links:Entrez Gene: 2294 Human
Omim: 601089 Human
SwissProt: Q12946 Human
Unigene: 155591 Human
Product Picture Sample:
Lane 1: Stomach (Mouse) Lysate at 40 ug
Lane 2: Lung (Mouse) Lysate at 40 ug
Lane 3: Urinary bladder (Mouse) Lysate at 40 ug
Lane 4: NIH/3T3 (Mouse) Cell Lysate at 30 ug
Primary: Anti-FOXF1 (SL2585R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 40 kD
Observed band size: 50 kD
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