Product Name	CXCL9
Chinese Name	γInterferon诱导单核cell factor抗体
Alias	MIG; CMK; C-X-C motif chemokine 9; CXCL9; chemokine (C-X-C motif) ligand 9; crg-10; Humig; monokine induced by gamma interferon; SCYB9; Small inducible cytokine B9; small inducible cytokine subfamily B member 9.
literatures	Specific References  (15)     |     SL2551R has been referenced in 15 publications. [IF=10.4] Yada, Akito, et al. "Splenectomy attenuates murine liver fibrosis with hypersplenism stimulating hepatic accumulation of Ly-6C lo macrophages."Journal of Hepatology (2015).  IHC-P ;  Mouse.   PubMed:26022691 [IF=7.109] Tan Rui-zhi. et al. Macrophages mediate psoriasis via Mincle-dependent mechanism in mice. CELL DEATH DISCOV. 2023 Apr;9(1):1-13  WB ;  Mouse.   PubMed:37117184 [IF=6.66] Clancy-Thompson, Eleanor, et al. "Melanoma induces, and adenosine suppresses, CXCR3-cognate chemokine production and T-cell infiltration of lungs bearing metastatic-like disease." Cancer immunology research 3.8 (2015): 956-967.  IHC-P ;  Mouse.   PubMed:26048575 [IF=5.58] Zhang, Qian-Qian, et al. "CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment." Scientific reports 5 (2015).  WB ;  Mouse.   PubMed:26526388 [IF=5.195] Jie Wang. et al. Huanglian Jiedu plaster ameliorated X-ray-induced radiation dermatitis injury by inhibiting HMGB1-mediated macrophage-inflammatory interaction. J ETHNOPHARMACOL. 2023 Feb;302:115917  WB, IHC ;  Human, Mouse.   PubMed:36414215 [IF=4.493] Fan Jiahui. et al. Study on the Correlation between Interleukin-27 and CXCL10 in Pulmonary Tuberculosis. J IMMUNOL RES. 2022;2022:2932837  IHC ;  Human.   PubMed:35785034 [IF=3.87] Cai, Zhaowei, et al. "Transcriptomic analysis of hepatic responses to testosterone deficiency in miniature pigs fed a high-cholesterol diet." BMC genomics 16.1 (2015): 59.  IHC-P ;  Pig.   PubMed:25887406 [IF=3.647] Hu Sun. et al. Study on the relationship between CXCR3 and its ligands and tubal tuberculosis. Life Sci. 2021 May;272:119047  IHC ;  Human.   PubMed:33454369 [IF=2.939] Yang R et al. Cordycepin Attenuates IFN-γ-Induced Macrophage IP-10 and Mig Expressions by Inhibiting STAT1 Activity in CFA-Induced Inflammation Mice Model. Inflammation. 2019 Dec 23.  IHC-P ;  Mouse.   PubMed:31873836 [IF=2.495] Xin Hu. et al. The role of CXCR3 and its ligands expression in Brucellar spondylitis. Bmc Immunol. 2020 Dec;21(1):1-8  IHC ;  Human.   PubMed:33208100 [IF=2.19] Sawano, Takeyuki, et al. "Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan." Oncology Reports.  IHC-P ;  Rat.   PubMed:25708528 [IF=2.15] Shimoura, Noriko, et al. "Interleukin (IL)-18, cooperatively with IL-23, induces prominent inflammation and enhances psoriasis-like epidermal hyperplasia." Archives of Dermatological Research (2017): 1-7.  IHC ;  Mouse.   PubMed:28299442 [IF=1.851] Wakasa Y et al. Delay in hepatocyte proliferation and prostaglandin D2 synthase expression for cholestasis due to endotoxin during partial hepatectomy in rats. Mol Med Rep. 2019 Sep 13.  IHC-P ;  Rat.   PubMed:31545425 [IF=1.785] Xiaoqian Shang. et al. Diagnostic value of CXCR3 and its ligands in spinal tuberculosis. Exp Ther Med. 2021 Jan;21(1):1-1  IHC ;  Human.   PubMed:33365073 [IF=0] Lee et al. Establishment of a chronic obstructive pulmonary disease mouse model based on the elapsed time after LPS intranasal instillation. (2018) Lab.Anim.Res. 34:01-Oct  IHC-P ;  Mouse.   PubMed:29628971
Research Area	Tumour  immunology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	14kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CXCL9: 23-125/125
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MIG (monokine induced by interferon-gamma), a member of the alpha-chemokine family (CXC) of cytokines, is produced by stimulated monocytes, macrophages and endothelial cells. It signals through the CXCR3 receptor. MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors. Human MIG is active on murine cells. Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3. Subcellular Location: Secreted. Similarity: Belongs to the intercrine alpha (chemokine CxC) family. SWISS: Q07325 Gene ID: 4283 Database links: Entrez Gene: 4283 Human Omim: 601704 Human SwissProt: Q07325 Human Unigene: 77367 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CXCL9) Polyclonal Antibody, Unconjugated (SL2551R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: human spleen tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CXCL9/MIG Polyclonal Antibody, Unconjugated(SL2551R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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