Product Name	CXCL5
Chinese Name	上皮中性粒细胞活化肽78抗体
Alias	AMCFII; C-X-C motif chemokine 5; Cxcl5; CXCL5_HUMAN; ENA-78(1-78); ENA-78(9-78); ENA78; Epithelial derived neutrophil activating peptide 78; Epithelial derived neutrophil activating protein 78; Epithelial-derived neutrophil-activating protein 78; GCP2; LIX; Neutrophil activating peptide ENA 78; Neutrophil-activating peptide ENA-78; SCYB5; Scyb6; Small inducible cytokine B5; Small inducible cytokine subfamily B member 5; Small-inducible cytokine B5.
literatures	Specific References  (14)     |     SL2549R has been referenced in 14 publications. [IF=21.95] Shi L et al. A Self‐Pumping Dressing for Draining Excessive Biofluid around Wounds. Adv Mater. 2019 Feb;31(5):e1804187.  IHC-P ;  Rat.   PubMed:30537340 [IF=20.011] Wang G et al. Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. (2016) Cancer.Disco. 6:80-95  IHC-P ;  Mouse.   PubMed:26701088 [IF=10.753] Xin Ge. et al. Epigenetic alterations of CXCL5 in Cr(VI)-induced carcinogenesis. SCI TOTAL ENVIRON. 2022 Jun;:155713  IHC ;  Mouse.   PubMed:35660107 [IF=9.995] Qicong Luo. et al. Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy. CELL REP. 2023 Apr 24;42(5):112437  IHC ;  Mouse.   PubMed:37097818 [IF=9.4] Nishida, Chinatsu. et al. Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation. Part Fibre Toxicol. 2022 Dec;19(1):1-17  IHC ;  Rat.   PubMed:35062982 [IF=5.773] Ting-Ting Chang. et al. Inhibition on CXCL5 reduces aortic matrix metalloproteinase 9 expression and protects against acute aortic dissection. Vasc Pharmacol. 2021 Oct;:106926  WB,IHC ;  Mouse .   PubMed:34653642 [IF=5.193] Bortell et al. Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro. (2017) J.Neuroinflammatio. 14:49  ICC ;  Rat.   PubMed:28279172 [IF=4.324] Chinatsu Nishida. et al. Predictive Biomarkers for the Ranking of Pulmonary Toxicity of Nanomaterials. Nanomaterials-Basel. 2020 Oct;10(10):2032  IHC ;  Rat.   PubMed:33076408 [IF=4.11] DAlessio, Franco R., et al. "Lung Angiogenesis Requires CD4+ Foxp3+ Regulatory T Cells." American Journal of Respiratory Cell and Molecular Biology (2014)  IHC-F ;  Mouse.   PubMed:25275926 [IF=3.31] Heilmann, Aline, et al. ʺThe Wnt Serpentine Receptor Frizzled-9 Regulates New Bone Formation in Fracture Healing.ʺ PloS one 8.12 (2013): e84232.  IHC-P ;  Mouse.   PubMed:24391920 [IF=3.146] Ito, Ryoji, et al. "A novel xenogeneic graft‐versus‐host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice." American Journal of Transplantation (2016).  IHC-P ;  Mouse.   PubMed:27862942 [IF=2.787] Randall-Demllo, Sarron, et al. "Characterisation of colonic dysplasia-like epithelial atypia in murine colitis." World J Gastroenterol 22.37 (2016): 8334-8348.  IHC-P ;  Mouse.   PubMed:27729740 [IF=2.57] Yasuyuki Higashi. et al. Pulmonary disorder induced by cross-linked polyacrylic acid. J OCCUP HEALTH. 2022 Dec;64(1):e12369  IHC ;  Rat.   PubMed:36459418 [IF=1.95] Gaballah, Mohammed Hassan, et al. "Simultaneous time course analysis of multiple markers based on DNA microarray in incised wound in skeletal muscle for wound aging." Forensic Science International (2016).  IHC-P ;  Mouse.   PubMed:27376479
Research Area	immunology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Mouse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	8/9kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse CXCL5: 51-132/132
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is an inflammatory chemokine that belongs to the CXC chemokine family. This chemokine is produced concomitantly with interleukin-8 (IL8) in response to stimulation with either interleukin-1 (IL1) or tumor necrosis factor-alpha (TNFA). This chemokine is a potent chemotaxin involved in neutrophil activation. [provided by RefSeq]. Function: May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation. Subcellular Location: Secreted. Post-translational modifications: GCP-2(1-78) and GCP-2(9-78) are produced by proteolytic cleavage after secretion from fibroblasts and epithelial cells. GCP-2(9-78) is the most prominent form. A number of additional N-terminal (processed between pos. 41 and 48) and C-terminal (processed between pos. 118 and 132) processed forms have been identified, probably also representing intermediate states. Similarity: Belongs to the intercrine alpha (chemokine CxC) family. SWISS: P50228 Gene ID: 20311 Database links: Entrez Gene: 6374 Human Entrez Gene: 20311 Mouse Omim: 600324 Human SwissProt: P42830 Human SwissProt: P50228 Mouse Unigene: 89714 Human Unigene: 4660 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (CXCL5) Polyclonal Antibody, Unconjugated (SL2549R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.

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