Product Name	CLEC2
Chinese Name	C型凝集素结构域家族1成员B抗体
Alias	C-type lectin domain family 1 member B; 1810061I13Rik; C type lectin domain family 1 member B; C type lectin like receptor 2; C-type lectin domain family 1, member B; C-type lectin-like receptor-2; CLEC 2; CLEC 2B; CLEC-2; CLEC2; CLEC2B; PRO1384; QDED721; CLC1B_HUMAN.
literatures	Specific References  (1)     |     SL2543R has been referenced in 1 publications. [IF=8.754] Xi-Xi Ni. et al. Regulation of the macrophage-hepatic stellate cell interaction by targeting macrophage PPARγ to prevent NASH progression in mice. LIVER INT. 2022 Sep;:  IF ;  Mouse.   PubMed:36165186
Research Area	Cell biology  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1μg/Test （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CLEC2: 1-100/329 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] Function: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. Subunit: Homodimer. Subcellular Location: Membrane; Single-pass type II membrane protein (Probable). Tissue Specificity: Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. Post-translational modifications: Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding. Similarity: Contains 1 C-type lectin domain. SWISS: Q9P126 Gene ID: 51266 Database links: Entrez Gene: 51266 Human Omim: 606783 Human SwissProt: Q9P126 Human Unigene: 221418 Human Unigene: 409794 Human
Product Picture	Blank control(Blue): Hepg2 Cells(fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-CLEC2/FITC Conjugated antibody (SL2543R /FITC), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/FITC(orange) ,used under the same conditions.

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