Product Name	CD72
Chinese Name	CD72蛋白抗体
Alias	B-cell differentiation antigen CD72; CD72b; B cell differentiation antigen CD72; CD72 antigen; CD72 molecule; CD72c; Ly-19; Ly-32; Ly-m19; Lyb-2; Lyb2; LYB2, mouse, homolog of; Lymphocyte antigen 32; MGC108873; CD72_HUMAN.
Research Area	Tumour  immunology  Stem cells  Cell Surface Molecule  glycoprotein  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD72: 4-110/359
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	CD72 antigen is a member of the type II integral membrane glycoproteins which includes other related cell surface molecules such as the asialoglycoprotein receptors, CD23 and the Kupffer cell receptor. The function of CD72 is unknown but the exposure of B cells to CD72 antibodies activates a variety of signaling pathways and can induce MHC class II expression and B cell proliferation. CD72 antigen is expressed on all cells of B cell lineage with the exception of plasma cells and weakly on human tissue macrophages. Function: Plays a role in B-cell proliferation and differentiation. Subunit: Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity). Subcellular Location: Membrane; Single-pass type II membrane protein. Tissue Specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells. Post-translational modifications: Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity). Similarity: Contains 1 C-type lectin domain. SWISS: P21854 Gene ID: 971 Database links: Entrez Gene: 971 Human Omim: 107272 Human SwissProt: P21854 Human Unigene: 116481 Human CD72是一个重要的B细胞特异性受体。属于II型膜内glycoprotein成员中的Cell Surface Molecule非唾液酸glycoprotein受体，虽然其分子功能目前还不清楚，但目前发现CD72的多态性与多种Tumour有关。
Product Picture	Blank control(blue):Raji cells (fixed with 2% paraformaldehyde (10 min)) . Primary Antibody:Rabbit Anti- CD72 antibody(SL2517R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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